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I want to apologize for the mess of this post last night. I did not give enough background for people to be able to asset me properly. (I probably shouldn't ever post with less than six hours of sleep in 48 hours and a migraine) Background on Queen: Friend texted me images of Queenie, asking if I or someone else had room for her. They work at a LFS and Queen was an owner drop off. She didn't fit in any of their tanks. Queen is over 18 inches including her tail and is 3LB, they offered her to me for a rehoming fee of $30 (they would have charged $100 for anyone else). I connected with @Anna to see if she would like Queen when their tank came in if I felt Queen was cramped in my 55 (she, in fact, can live in my 55, but would be much better off in a larger tank). Queen came to me with pronounced red veins, little interest in food, and was lethargic, which is to be expected. I added a little bit of AQ salt to her tank and half dose of Paragaurd (it contains Methylene Blue. It helps with blood oxygenation). Her QT is 30x10 and about 25 gallons in volume. Had a sponge filter and an air stone. A few days later she had bleeding into her fins. (See images) I consulted with another aquarium group. They recommended oral kanamycin. I used Seachem Kanaplex with Seachem Focus and Garlicguard with frozen food. That seemed to get her to eat. While I began treatment with Queen, a goldfish in my main tank started showing the same symptoms. I do not know if cross contamination happened, but I consulted the group again, we decided to move them into the same QT for treatment. About a day after I started treatment they both developed open sores on their bellies (see image), and their fins had a shredded look to them. I continued treatment with the oral meds, they seemed to be recovered after it course was over. I stopped meds and waited a few days. They both relapsed and started bleeding under the skin. (see image) Talked to the same group, we agreed to started them on tetracycline. They appeared to be completely recovered. Active and eating, just some red veins. Stopped medication. A few days later, Ponyo started some bleeding into her fins and Queen was again bleeding into her fins, skin, was lethargic, and had sores. She was eating though. Talk to the same group and called some of my old aquarium buddies and we all agreed to do a round of Triple-sulfa and start Medi-gold. They both again recovered, I stopped the Triple-sulfa but continued the Medi-gold and added in a half dose of Nitro-blue (Active Ingredients: Nitrofurazone and Methylene Blue) to help with blood oxygen levels. Discontinued the Nitro-blue after a week still doing well. Do to some tank issues had to move my two-remaining fish into the QT tank for two weeks. I understand it isn’t ideal or even okay. The new tank I had gotten was a leaker and I had to sort out another new one. Took a few weeks to get the help I needed to transport a new 55. I didn’t think my goldfish could survive in a 5 gallon bucket for more than a few hours at their size. Everyone was doing fantastic. Moved them all into the 55. Kept them all on the Medi-gold for another week after moving into the 55. No one else is ill but Queen started bleeding into her fins again, and has some very light pine-coning. I have been trying to get an accurate picture. I did give them one dose of Metro-Med, decided better of it, and gave her an Epson salt dip. The Medi-Gold and Metro-med were still sealed at time of use and have an expiration date of 2018. So they were still safe to use. Any advice on what to do?